OcrV1, Main, Exploration, bibRecord, 001808

Antidepressant medication use and breast cancer risk: a case-control study. Commentary : Mental Health

Identifieur interne : 001808 ( Main/Exploration ); précédent : 001807; suivant : 001809

Antidepressant medication use and breast cancer risk: a case-control study. Commentary : Mental Health

Auteurs : Allan Steingart [Canada] ; Michelle Cotterchio [Canada] ; Nancy Kreiger [Canada] ; Margaret Sloan [Canada] ; K. Mcpherson [Royaume-Uni]

Source :

International journal of epidemiology [ 0300-5771 ] ; 2003.

RBID : Pascal:04-0149242

Descripteurs français

Pascal (Inist)
- Etat dépressif, Glande mammaire, Facteur risque, Etude cas témoin, Chimiothérapie, Antidépresseur, Tumeur maligne, Femelle, Homme, Cancer du sein.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Antidepressant agent, Breast cancer, Case control study, Chemotherapy, Depression, Female, Human, Malignant tumor, Mammary gland, Risk factor.

Abstract

Background Animal and human studies have reported an association between antidepressant (AD) medication use and breast cancer risk. A population-based case-control study was designed specifically to examine this association among women in Ontario, Canada. Methods The Ontario Cancer Registry (OCR) identified women diagnosed with primary breast cancer. Controls, randomly sampled from the female population of Ontario, were frequency matched by 5-year age groups. A mailed self-administered questionnaire included questions about lifetime use of AD and potential confounders. Multivariate logistic regression yielded odds ratio estimates. Results 'Ever' use of AD was reported by 14% (441/3077) cases versus 12% (372/2994) controls. The age-adjusted odds ratio (AOR) for 'ever' use was 1.17, (95% CI: 1.01, 1.36). An increased risk was also observed for selective serotonin reuptake inhibitors = 1.33 (95% CI: 1.07, 1.66), Sertraline = 1.58 (95% CI: 1.03, 2.41), and Paroxetine = 1.55 (95% CI: 1.00, 2.40). None of the 30 variables assessed for confounding altered the risk estimate by more than 10%. Multivariate adjustment including all possible breast cancer risk factors yielded an unchanged, but not significant, point estimate (MVOR = 1.2, 95% CI: 0.96, 1.51). No relationship was observed for duration or timing of AD use. Conclusions A modest association between 'ever' use of AD and breast cancer was found using the most parsimonious multivariate model. OR estimates did not change, but CI were widened and statistical significance lost, after adjustment for factors associated with breast cancer risk.

Affiliations:

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antidepressant agent</term>
<term>Breast cancer</term>
<term>Case control study</term>
<term>Chemotherapy</term>
<term>Depression</term>
<term>Female</term>
<term>Human</term>
<term>Malignant tumor</term>
<term>Mammary gland</term>
<term>Risk factor</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Etat dépressif</term>
<term>Glande mammaire</term>
<term>Facteur risque</term>
<term>Etude cas témoin</term>
<term>Chimiothérapie</term>
<term>Antidépresseur</term>
<term>Tumeur maligne</term>
<term>Femelle</term>
<term>Homme</term>
<term>Cancer du sein</term>
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<front><div type="abstract" xml:lang="en">Background Animal and human studies have reported an association between antidepressant (AD) medication use and breast cancer risk. A population-based case-control study was designed specifically to examine this association among women in Ontario, Canada. Methods The Ontario Cancer Registry (OCR) identified women diagnosed with primary breast cancer. Controls, randomly sampled from the female population of Ontario, were frequency matched by 5-year age groups. A mailed self-administered questionnaire included questions about lifetime use of AD and potential confounders. Multivariate logistic regression yielded odds ratio estimates. Results 'Ever' use of AD was reported by 14% (441/3077) cases versus 12% (372/2994) controls. The age-adjusted odds ratio (AOR) for 'ever' use was 1.17, (95% CI: 1.01, 1.36). An increased risk was also observed for selective serotonin reuptake inhibitors = 1.33 (95% CI: 1.07, 1.66), Sertraline = 1.58 (95% CI: 1.03, 2.41), and Paroxetine = 1.55 (95% CI: 1.00, 2.40). None of the 30 variables assessed for confounding altered the risk estimate by more than 10%. Multivariate adjustment including all possible breast cancer risk factors yielded an unchanged, but not significant, point estimate (MVOR = 1.2, 95% CI: 0.96, 1.51). No relationship was observed for duration or timing of AD use. Conclusions A modest association between 'ever' use of AD and breast cancer was found using the most parsimonious multivariate model. OR estimates did not change, but CI were widened and statistical significance lost, after adjustment for factors associated with breast cancer risk.</div>
</front>
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<name sortKey="Kreiger, Nancy" sort="Kreiger, Nancy" uniqKey="Kreiger N" first="Nancy" last="Kreiger">Nancy Kreiger</name>
<name sortKey="Kreiger, Nancy" sort="Kreiger, Nancy" uniqKey="Kreiger N" first="Nancy" last="Kreiger">Nancy Kreiger</name>
<name sortKey="Kreiger, Nancy" sort="Kreiger, Nancy" uniqKey="Kreiger N" first="Nancy" last="Kreiger">Nancy Kreiger</name>
<name sortKey="Sloan, Margaret" sort="Sloan, Margaret" uniqKey="Sloan M" first="Margaret" last="Sloan">Margaret Sloan</name>
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<country name="Royaume-Uni"><noRegion><name sortKey="Mcpherson, K" sort="Mcpherson, K" uniqKey="Mcpherson K" first="K." last="Mcpherson">K. Mcpherson</name>
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Antidepressant medication use and breast cancer risk: a case-control study. Commentary : Mental Health

Antidepressant medication use and breast cancer risk: a case-control study. Commentary : Mental Health

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri